Editorial: Neuronal Development and Degeneration

Diabetes Mellitus Type1 and Neuronal Degeneration in Ventral and Dorsal Hippocampus

  Background and Objectives: Studies have documented the morhplogical, neurochemical and functional difference between the dorsal and ventral zones of hippocampus. The aim of this study was to assess the effects of chronic diabetes mellitus type1 on ventral and dorsal zones of hippocampus. Methods: Experimental diabetes was induced by stereptozotocin at a dose of 60 mg/kg. At the end of 8 wee...

The Identification of Novel Mechanisms in Neuronal Development and Degeneration

The goal of this dissertation is to further understand two key, broad processes which occur over the course of a neuron's lifetime: its development and possible degeneration in disease. We identify novel components in both of these processes and attempt to understand the functional significance as well as the mechanism each component uses to exert its effects. We begin with work done focusing o...

Editorial: Neuronal Mechanics and Transport

Past research on nervous system development was largely centered on the role of molecules and biochemical signaling cascades. However, recent biophysical work has clearly demonstrated the additional importance of forces in shaping neuronal morphology and driving intracellular transport as well as the role of stiffness for cellular behavior. The research topic “Neuronal Mechanics and Transport” ...

Neuronal degeneration and mitochondrial dysfunction.

Editorial Note: Membranes for Development